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Pharmacotherapy. 2002 Mar;22(3):303-9.

Association between acetaminophen or nonsteroidal antiinflammatory drugs and risk of developing ovarian, breast, or colon cancer.

Author information

1
Division of Clinical Pharmacology and Toxicology, University Hospital Basel, Switzerland. Christoph.Meier@unibas.ch

Abstract

STUDY OBJECTIVE:

To explore the association between exposure to acetaminophen (paracetamol) or nonsteroidal antiinflammatory drugs (NSAIDs) and risk of developing ovarian, breast, or colon cancer.

DESIGN:

Retrospective case-control study

SETTING:

General practice offices.

SUBJECTS:

Four hundred eighty-three women with ovarian cancer and 1877 women matched for age, years of medical history in computer record, general practice attended, and calendar time; 3706 women with breast cancer and 14,155 matched control subjects; and 635 women with colon cancer and 2434 matched control subjects.

INTERVENTION:

United Kingdom-based General Practice Research Database was searched for women aged 50-89 years with a first-time diagnosis of ovarian, breast, or colon cancer and for matched controls to assess prescription analgesic exposure.

MEASUREMENTS AND MAIN RESULTS:

Regular acetaminophen exposure (> or = 30 prescriptions) was associated with a slightly decreased risk of developing breast (odds ratio [OR] 0.8, 95% confidence interval [CI] 0.7-1.0) but not ovarian (OR 1.0, 95% CI 0.6-1.5) or colon (OR 1.0, 95% Cl 0.7-1.4) cancer. Regular NSAID exposure was associated with a reduced risk of colon (OR 0.5, 95% CI 0.3-0.9) but not ovarian or breast cancer.

CONCLUSION:

We found no evidence for a decreased ovarian cancer risk for women with regular acetaminophen or NSAID exposure.

PMID:
11898889
[Indexed for MEDLINE]

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