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Vitam Horm. 2002;64:357-406.

Antiproliferative action of vitamin D.

Author information

1
Graduate School of Biomedicine, Department of Cell Biology, 33014 University of Tampere, Finland.

Abstract

During the past few years, it has become apparent that vitamin D may play an important role in malignant transformation. Epidemiological studies suggest that low vitamin D serum concentration increases especially the risk of hormone-related cancers. Experimentally, vitamin D suppresses the proliferation of normal and malignant cells and induces differentiation and apoptosis. In the present review we discuss the mechanisms whereby vitamin D regulates cell proliferation and whether it could be used in prevention and treatment of hyperproliferative disorders like cancers.

PMID:
11898396
DOI:
10.1016/s0083-6729(02)64010-5
[Indexed for MEDLINE]

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