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Nat Genet. 2002 Apr;30(4):363-4. Epub 2002 Mar 18.

Micro RNAs are complementary to 3' UTR sequence motifs that mediate negative post-transcriptional regulation.

Author information

1
University of California at Berkeley, Department of Molecular and Cell Biology, 545 Life Sciences Addition #3200, Berkeley, California 94720-3200, USA. lai@fruitfly.bdgp.berkeley.edu

Abstract

Micro RNAs are a large family of noncoding RNAs of 21-22 nucleotides whose functions are generally unknown. Here a large subset of Drosophila micro RNAs is shown to be perfectly complementary to several classes of sequence motif previously demonstrated to mediate negative post-transcriptional regulation. These findings suggest a more general role for micro RNAs in gene regulation through the formation of RNA duplexes.

PMID:
11896390
DOI:
10.1038/ng865
[Indexed for MEDLINE]

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