Format

Send to

Choose Destination
Curr Top Med Chem. 2001 Aug;1(3):193-7.

Alpha2-adrenergic receptor agonists as analgesics.

Author information

1
Drug Discovery Division, R. W. Johnson Pharmaceutical Research Institute, Spring House, PA 19477, USA. RBOYD@prius.jnj.com

Abstract

Alpha2-adrenergic receptor agonists are analgesic agents, and the alpha2-adrenergic agonist clonidine has been used in clinical studies for regional analgesia after intrathecal administration. We review here recent developments concerning the structure activity relationships of a new class of potent alpha2-adrenergic agonists and their use as analgesic agents. The effect of structure upon cardiovascular side-effects is also monitored, such as the prolongation of the QT portion of the cardiac action potential.

PMID:
11895135
DOI:
10.2174/1568026013395182
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Bentham Science Publishers Ltd.
Loading ...
Support Center