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Curr Opin Cell Biol. 2002 Apr;14(2):196-202.

Regulation of cell polarity during eukaryotic chemotaxis: the chemotactic compass.

Author information

1
Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue/C-1, 502, Boston, MA 02115, USA. orion_weiner@hms.harvard.edu

Abstract

Phosphatidylinositol 3-kinase lipid products and the Rho GTPases play a central role in transmitting information from chemotactic receptors to the effectors of cell polarity, and recent advances in the field have allowed us to understand these roles more clearly. Emergent properties of positive and negative regulation of these molecules may account for the establishment of cell polarity during chemotaxis for a wide range of cells from Dictyostelium to fibroblasts to neutrophils.

PMID:
11891119
PMCID:
PMC2819118
DOI:
10.1016/s0955-0674(02)00310-1
[Indexed for MEDLINE]
Free PMC Article

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