Send to

Choose Destination
Curr Opin Cell Biol. 2002 Apr;14(2):149-54.

How signaling proteins integrate multiple inputs: a comparison of N-WASP and Cdk2.

Author information

Institute of Molecular Biology, Department of Chemistry, 1229 University of Oregon, Eugene, OR 97403-1229, USA.


Signal transduction proteins that can integrate multiple upstream signals play a critical role in the complex regulatory circuits that control cellular behavior. The two signaling node proteins cyclin-dependent kinase 2 and the actin regulator neuronal Wiskott-Aldrich syndrome protein have qualitatively similar signaling properties. Recent studies, however, reveal that these proteins utilize distinct mechanisms of signal integration, leading to subtle but important quantitative differences in behavior.

[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center