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Curr Opin Cell Biol. 2002 Apr;14(2):149-54.

How signaling proteins integrate multiple inputs: a comparison of N-WASP and Cdk2.

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1
Institute of Molecular Biology, Department of Chemistry, 1229 University of Oregon, Eugene, OR 97403-1229, USA.

Abstract

Signal transduction proteins that can integrate multiple upstream signals play a critical role in the complex regulatory circuits that control cellular behavior. The two signaling node proteins cyclin-dependent kinase 2 and the actin regulator neuronal Wiskott-Aldrich syndrome protein have qualitatively similar signaling properties. Recent studies, however, reveal that these proteins utilize distinct mechanisms of signal integration, leading to subtle but important quantitative differences in behavior.

PMID:
11891112
[Indexed for MEDLINE]

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