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Neurology. 2002 Mar 12;58(5):814-6.

Spontaneous CSF leaks: underlying disorder of connective tissue.

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Department of Neurology, Mayo Clinic, Rochester, MN 55905, USA.


Of 58 consecutive patients with spontaneous CSF leaks, nine exhibited features of connective tissue disorder. One had Marfan's syndrome. Five additional patients had hyperflexible joints, of whom four had arachnodactyly, four were tall and slender, two had hyperextensible skin, and one had a strong family history of abdominal aorta aneurysms. Retinal detachment at a young age was noted in two. One patient had bilateral carotid dissections. A dural weakness may predispose patients to spontaneous CSF leak.

[Indexed for MEDLINE]

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