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Gut. 2002 Apr;50(4):571-81.

Hepatic stellate cells: role in microcirculation and pathophysiology of portal hypertension.

Author information

1
Laboratory for Molecular Liver Cell Biology, Free University Brussels (VUB), Brussels, Belgium. Hendrik.Reynaert@az.vub.ac.be

Abstract

Accumulating evidence suggests that stellate cells are involved in the regulation of the liver microcirculation and portal hypertension. Activated hepatic stellate cells have the necessary machinery to contract or relax in response to a number of vasoactive substances. Because stellate cells play a role in both fibrosis and portal hypertension, they are currently regarded as therapeutic targets to prevent and treat the complications of chronic liver disease.

PMID:
11889082
PMCID:
PMC1773176
[Indexed for MEDLINE]
Free PMC Article
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