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Cancer Lett. 2002 May 28;179(2):113-9.

Synergistic tumor promoter effects of estrone and progesterone in methylnitrosourea-induced rat mammary cancer.

Author information

1
Department of Obstetrics and Gynecology, Indiana University School of Medicine, 975 West Walnut Street (IB360), Indianapolis, IN 46202, USA. rbigsby@iupui.edu

Abstract

Tumor promoter effects of steroid hormones were tested in ovariectomized rats treated with the tumor initiator, methylnitrosourea. Continuous treatment with low doses of estrone induced tumor in 55% of experimental animals while intact control animals had a 96-100% incidence. Although progesterone alone produced no tumors in ovariectomized, methylnitrosourea-treated animals, estrone and progesterone acted synergistically, inducing tumorigenesis in 88% of treated rats. These results point to an important interaction between estrogens and progestins in promoting mammary tumorigenesis.

PMID:
11888665
DOI:
10.1016/s0304-3835(02)00032-0
[Indexed for MEDLINE]

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