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Indian J Med Sci. 2001 Sep;55(9):495-500.

Early diagnosis of neonatal sepsis using a hematological scoring system.

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1
Dept of Pathology, Dept of Pediatrics, Tata Main Hospital, Jamshedpur.

Abstract

OBJECTIVE:

To assess the utility of the hematologic scoring system (HSS) of Rodwell et al for the early detection of neonatal sepsis.

DESIGN:

Analysis of the peripheral smear findings according to the HSS by a pathologist blinded to the infection status of the neonate.

SUBJECTS:

One hundred and three high risk neonates having predisposing perinatal factors or clinical suspicion of sepsis.

RESULTS:

Analysis of the hematologic profiles in the light of the HSS found that an abnormal immature to total neutrophil (1:T) ratio followed by an abnormal immature to mature neutrophil (1:M) ratio were the most sensitive indicators in identifying infants with sepsis. These two criteria along with thrombocytopenia (< 1,50,000/cm3) had a high negative predictive value over 94%. The study also found that the higher the score the greater the certainty of sepsis being present.

CONCLUSION:

The HSS is simple, quick, cost effective and readily available tool in the early-diagnosis of neonatal sepsis and could provide a guideline to decisions regarding antibiotic therapy.

PMID:
11887300
[Indexed for MEDLINE]
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