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Virology. 2002 Mar 1;294(1):70-4.

An antibody that prevents the hemagglutinin low pH fusogenic transition.

Author information

1
Laboratoire d'Enzymologie et Biochimie Structurales, UPR 9063 CNRS, Bât. 34, CNRS, 91198 Gif-sur-Yvette Cedex, France.

Abstract

We have determined the structure of a complex of influenza hemagglutinin (HA) with an antibody that binds simultaneously to the membrane-distal domains of two HA monomers, effectively cross-linking them. The antibody prevents the low pH structural transition of HA that is required for its membrane fusion activity, providing evidence that a rearrangement of HA membrane-distal domains is an essential component of the transition.

PMID:
11886266
DOI:
10.1006/viro.2001.1320
[Indexed for MEDLINE]
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