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Mol Cell. 2001 Dec;8(6):1160-1.

NHEJ deficiency and disease.

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1
Cell Biology Program, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA.

Abstract

In mouse and human, diseases associated with deficiency of DNA ligase IV, a protein involved in DNA double-strand break repair, have been identified. Manifestation of some of these disease phenotypes, namely tumorigenesis, may require additional checkpoint deficiencies.

PMID:
11885597
[Indexed for MEDLINE]
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