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Breast Cancer Res Treat. 2002 Jan;71(2):145-7.

Minor role for BRCA2 (exon11) and p53 (exon 5-9) among Sudanese breast cancer patients.

Author information

1
Institute of Endemic Diseases, University of Khartoum, Sudan.

Abstract

A cohort of 20 breast cancer patients from the Sudan was tested for germ line and somatic mutation in their BRCA2 exon 11 as well as the main conserved area of the p53 tumor suppressor gene. The results indicate that both regions may play a limited role in the pathogenesis of breast cancer in those patients. The fact that there are no somatic mutations detected in p53 was particularly surprising as the expected rate for mutations in breast cancer is 30-50%.

PMID:
11883440
[Indexed for MEDLINE]

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