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Microbes Infect. 2002 Feb;4(2):225-35.

Actinobacillus pleuropneumoniae: pathobiology and pathogenesis of infection.

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Molecular Infectious Diseases Group, Department of Paediatrics, Faculty of Medicine, Imperial College, St. Mary's Campus, W2 1PG, London, UK.


Actinobacillus pleuropneumoniae causes porcine pleuropneumonia, a highly contagious disease for which there is no effective vaccine. This review considers how adhesins, iron-acquisition factors, capsule and lipopolysaccharide, RTX cytotoxins and other potential future vaccine components contribute to colonisation, to avoidance of host clearance mechanisms and to damage of host tissues.

[Indexed for MEDLINE]

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