Antibiotic-resistant enterococci: the mechanisms and dynamics of drug introduction and resistance

Brett D Shepard; Michael S Gilmore

doi:10.1016/s1286-4579(01)01530-1

Antibiotic-resistant enterococci: the mechanisms and dynamics of drug introduction and resistance

Microbes Infect. 2002 Feb;4(2):215-24. doi: 10.1016/s1286-4579(01)01530-1.

Authors

Brett D Shepard¹, Michael S Gilmore

Affiliation

¹ Department of Microbiology and Immunology, University of Oklahoma Health Sciences Center, 975 NE 10th St., BRC 356, Oklahoma City, Oklahoma, USA.

PMID: 11880055
DOI: 10.1016/s1286-4579(01)01530-1

Abstract

Enterococci possess a vast array of mechanisms to resist the lethal effects of most antimicrobial drugs currently approved for therapeutic use in humans, thus presenting a considerable therapeutic challenge. This review summarizes current concepts regarding the mechanisms of resistance, as well as the emergence, proliferation, and epidemiology of resistant enterococci.

Publication types

Review

MeSH terms

Animals
Anti-Bacterial Agents / pharmacology*
Anti-Bacterial Agents / therapeutic use
Disease Reservoirs
Drug Resistance, Multiple, Bacterial*
Enterococcus / drug effects*
Enterococcus / physiology
Gram-Positive Bacterial Infections / drug therapy
Gram-Positive Bacterial Infections / epidemiology
Gram-Positive Bacterial Infections / microbiology
Humans
Prevalence

Substances

Anti-Bacterial Agents