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Microbes Infect. 2002 Feb;4(2):165-74.

Mechanisms of resistance of Plasmodium falciparum to antimalarial drugs.

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1
Department of Biomolecular Sciences, University of Manchester Institute of Science and Technology, P.O. Box 88, M60 1QD, Manchester, UK. john.hyde@umist.ac.uk

Abstract

Chemotherapy and chemoprophylaxis are the principal means of combating malaria parasite infections in the human host. In the last 75 years, since the introduction of synthetic antimalarials, only a small number of compounds have been found suitable for clinical usage, and this limited armoury is now greatly compromised by the spread of drug-resistant parasite strains. Our current knowledge of the molecular mechanisms underlying resistance in the lethal species Plasmodium falciparum is reviewed here.

PMID:
11880048
[Indexed for MEDLINE]
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