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Dev Cell. 2002 Mar;2(3):256-7.

Apoptosome: the seven-spoked death machine.

Author information

1
Program in Apoptosis and Cell Death Research, The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA.

Abstract

A paper in the February issue of Molecular Cell describes the structure of the apoptosome, a multicomponent death machine, deciphered by cryoelectron microscopy. This structure explains the assembly of the machine, the tentative location of the subcomponents, and proposes a mechanism for initiating the death signal.

PMID:
11879630
DOI:
10.1016/s1534-5807(02)00137-5
[Indexed for MEDLINE]
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