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Dev Cell. 2002 Mar;2(3):251-2.

Oxidants painting the cysteine chapel: redox regulation of PTPs.

Author information

1
Cardiovascular Branch, NHLBI, National Institutes of Health, Bethesda, MD 20892, USA.

Abstract

Growth factors and cytokines appear to stimulate the intracellular production of reactive oxygen species (ROS). Evidence suggests that this alteration in the cellular redox state is essential for downstream signaling, but the precise mechanism has remained elusive. A new study now demonstrates that ligand-stimulated intracellular hydrogen peroxide can specifically and reversibly regulate the activity of protein tyrosine phosphatases.

PMID:
11879627
DOI:
10.1016/s1534-5807(02)00132-6
[Indexed for MEDLINE]
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