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Mol Biotechnol. 2002 Jan;20(1):17-28.

Classification of protein folds.

Author information

1
SmithKline Beecham Pharmaceuticals, Research & Development, Bioinformatics Research Group, New Frontiers Science Park (North), Harlow, Essex, UK. russell@embl-heidelberg.de

Abstract

Classification is central to many studies of protein structure, function, and evolution. This article presents a strategy for classifying protein three-dimensional structures. Methods for and issues related to secondary structure, domain, and class assignment are discussed, in addition to methods for the comparison of protein three-dimensional structures. Strategies for assigning protein domains to particular folds and homologous superfamilies are then described in the context of the currently available classification schemes. Two examples (adenylate cyclase/DNA polymerase and glycogen phosphorylase/beta-glucosyltransferase) are presented to illustrate problems associated with protein classification.

PMID:
11876296
DOI:
10.1385/MB:20:1:017
[Indexed for MEDLINE]

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