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Nature. 2002 Feb 28;415(6875):977-83.

MAP kinase signalling cascade in Arabidopsis innate immunity.

Author information

1
Department of Genetics, Harvard Medical School, Boston, Massachusetts 02114, USA.

Abstract

There is remarkable conservation in the recognition of pathogen-associated molecular patterns (PAMPs) by innate immune responses of plants, insects and mammals. We developed an Arabidopsis thaliana leaf cell system based on the induction of early-defence gene transcription by flagellin, a highly conserved component of bacterial flagella that functions as a PAMP in plants and mammals. Here we identify a complete plant MAP kinase cascade (MEKK1, MKK4/MKK5 and MPK3/MPK6) and WRKY22/WRKY29 transcription factors that function downstream of the flagellin receptor FLS2, a leucine-rich-repeat (LRR) receptor kinase. Activation of this MAPK cascade confers resistance to both bacterial and fungal pathogens, suggesting that signalling events initiated by diverse pathogens converge into a conserved MAPK cascade.

PMID:
11875555
DOI:
10.1038/415977a
[Indexed for MEDLINE]

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