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Nat Cell Biol. 2002 Mar;4(3):260-9.

Formins direct Arp2/3-independent actin filament assembly to polarize cell growth in yeast.

Author information

1
Department of Biology, Queen's University, Kingston, Ontario, Canada.

Abstract

Formins have been implicated in the regulation of cytoskeletal structure in animals and fungi. Here we show that the formins Bni1 and Bnr1 of budding yeast stimulate the assembly of actin filaments that function as precursors to tropomyosin-stabilized cables that direct polarized cell growth. With loss of formin function, cables disassemble,whereas increased formin activity causes the hyperaccumulation of cable-like filaments. Unlike the assembly of cortical actin patches, cable assembly requires profilin but not the Arp2/3 complex. Thus formins control a distinct pathway for assembling actin filaments that organize the overall polarity of the cell.

PMID:
11875440
DOI:
10.1038/ncb770
[Indexed for MEDLINE]

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