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Fertil Steril. 2002 Mar;77(3):526-8.

Effect of hypertension therapy with the angiotensin-converting enzyme inhibitor lisinopril on hyperandrogenism in women with polycystic ovary syndrome.

Author information

1
Infertility Unit, Department of Obstetrics and Gynecology, Sani Konukoglu Hospital, Gaziantep, Turkey. bhacihanefioglu@hotmail.com

Abstract

OBJECTIVE:

To investigate the effect of an angiotensin-converting enzyme inhibitor, lisinopril, on serum androgen and sex-hormone-binding globulin (SHBG) levels in hypertensive women with polycystic ovary syndrome (PCOS).

DESIGN:

Prospective, observational study.

SETTING:

Infertility Clinic of the Sani Konukoglu Hospital, Gaziantep, Turkey.

PATIENT(S):

Ten hypertensive women with PCOS.

INTERVENTION(S):

Lisinopril, 10 mg/day, for 4 weeks. MAIN OUTCOME MEASURE(S)): Serum levels of gonadotropins, DHEAS, total T, free T, 17 alpha-hydroxyprogesterone (17-OHP), androstenedione, E2, SHBG, TSH, and PRL were determined.

RESULT(S):

Hypertension treatment with lisinopril (10 mg/day for 4 weeks) resulted in a statistically significant decrease in serum free T levels. However, there was no difference in the SHBG levels.

CONCLUSION(S):

Use of lisinopril, an angiotensin-converting enzyme inhibitor, results in decreased free T levels independently of SHBG. It may affect the free T levels by affecting the ovarian renin-angiotensin system.

PMID:
11872207
[Indexed for MEDLINE]

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