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Fertil Steril. 2002 Mar;77(3):481-6.

Effects of hormone replacement therapy and methylenetetrahydrofolate reductase polymorphism on plasma folate and homocysteine levels in postmenopausal Japanese women.

Author information

1
Department of Obstetrics and Gynecology, Toride Kyodo General Hospital, Toride, Japan. pv2t-sigi@asashi-net.or.jp

Abstract

OBJECTIVE:

To evaluate the relationships among the methylenetetrahydrofolate reductase (MTHFR) polymorphism, plasma folate, total homocysteine (Hcy) levels, lipids, and the reduction of Hcy levels resulting from hormone replacement therapy (HRT).

DESIGN:

Clinical study.

SETTING:

Outpatient department of obstetrics and gynecology in a general hospital.

PATIENT(S):

Two hundred seventeen postmenopausal Japanese women.

INTERVENTION(S):

Of the 217 women, 172 patients were under continuous treatment with oral conjugated equine estrogen and medroxyprogesteron acetate.

MAIN OUTCOME MEASURE(S):

Fasting Hcy, folate, methionine, lipids, and apolipoproteins were measured before and after 3 months of HRT.

RESULT(S):

The plasma Hcy concentration was significantly higher in the low folate than in the high-folate group only in patients with the homozygous (T/T) mutant. Plasma Hcy concentrations were significantly correlated with age (R = 0.64, P=.02) or years since menopause (R = 0.73, P=.02) only in the low-folate group with T/T. The plasma Hcy concentration decreased significantly in all genotypes after 3 months of HRT, but the levels of serum folate and methionine remained unchanged.

CONCLUSION(S):

The MTHFR polymorphism was associated with a higher Hcy concentration, and this association was related to the serum folate level. Hormone replacement therapy reduced the plasma Hcy concentration independently of the MTHFR polymorphism.

PMID:
11872199
DOI:
10.1016/s0015-0282(01)03228-9
[Indexed for MEDLINE]

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