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Fertil Steril. 2002 Mar;77(3):468-71.

Early follicular serum müllerian-inhibiting substance levels are associated with ovarian response during assisted reproductive technology cycles.

Author information

1
Department of Obstetrics, Gynecology and Reproductive Sciences, Division of Reproductive Endocrinology and Infertility, UMDNJ--Robert Wood Johnson Medical School, New Brunswick, New Jersey 08901, USA. seiferb@umdnj.edu

Abstract

OBJECTIVE:

To test the hypothesis that the concentration of early follicular phase serum müllerian-inhibiting substance (MIS) is associated with ovarian response in women undergoing ovulation induction in preparation for assisted reproductive technology (ART).

DESIGN:

Retrospective analysis of frozen day 3 serum samples.

SETTING:

Academic ART program.

PATIENT(S):

One sample of frozen day 3 serum from women with < or = 6 retrieved oocytes (n = 28) compared with women with > or = 11 oocytes retrieved (n = 79) in preparation for IVF.

INTERVENTION(S):

None.

MAIN OUTCOME MEASURE(S):

Comparison of day 3 serum MIS levels between two groups of women. Other comparisons included maximum serum E(2) concentrations, number of retrieved oocytes, and percentage of mature oocytes between groups.

RESULT(S):

Mean serum MIS concentrations were 1.0 +/- 0.4 ng/mL compared with 2.5 +/- 0.3 ng/mL, or more than a 2.5-fold greater serum concentration of MIS in the group with > or = 11 oocytes retrieved compared with in the group with < or = 6 retrieved oocytes.

CONCLUSION(S):

These data demonstrate an association between early follicular phase serum MIS and the number of retrieved oocytes. Higher day 3 serum MIS concentrations were associated with greater number of retrieved oocytes.

PMID:
11872196
[Indexed for MEDLINE]

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