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J Org Chem. 2002 Mar 8;67(5):1607-12.

Total synthesis of the ethyl ester of the major urinary metabolite of prostaglandin E(2).

Author information

1
Department of Chemistry & Biochemistry, University of Delaware, Newark, Delaware 19716, USA. taberd@udel.edu

Abstract

The preparation of the ethyl ester of the major urinary metabolite of prostaglandin E(2) 3 is described. The key step is the kinetic opening of the TBS-protected bicyclic ketone 7 with thiophenol.

PMID:
11871893
DOI:
10.1021/jo011017i
[Indexed for MEDLINE]

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