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Curr Opin Immunol. 2002 Apr;14(2):165-71.

NKT cells - conductors of tumor immunity?

Author information

1
Cancer Immunology, Trescowthick Laboratories, Peter MacCallum Cancer Institute, East Melbourne, Victoria, Australia. m.smyth@pmci.unimelb.edu.au

Abstract

NKT cells are key players in the regulation of antitumor immunity, particularly in experimental models of tumor immunotherapy, such as IL-12 or alpha-galactosylceramide administration. They may also operate in natural antitumor immunity. NKT cells are best known for their immunosuppressive functions; however, NKT cells interact with a range of other cell types (particularly dendritic cells and NK cells) and the outcome of NKT-cell stimulation depends on these and on the cytokine/co-stimulatory milieu.

PMID:
11869887
DOI:
10.1016/s0952-7915(02)00316-3
[Indexed for MEDLINE]

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