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Radiology. 2002 Mar;222(3):789-93.

Morphologic phenotyping with MR microscopy: the visible mouse.

Author information

1
Center for In Vivo Microscopy, Duke University Medical Center, Rm 141, D Bryan Neuroscience Bldg, Research Dr, Durham, NC 27710, USA. gaj@orion.mc.duke.edu

Abstract

A method for rapid morphologic phenotyping is demonstrated by using magnetic resonance microscopy. Whole fixed C57BL/6J mice were imaged at 110-microm isotropic resolution; limited volumes of the intact specimen, at 50-microm isotropic resolution; and isolated organs, at 25-microm isotropic resolution. The three-dimensional imaging technique was applied to uricase knockout mice to demonstrate the method for the evaluation of morphologic phenotype.

PMID:
11867802
DOI:
10.1148/radiol.2223010531
[Indexed for MEDLINE]

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