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Radiology. 2002 Mar;222(3):782-8.

Pulmonary arterial hypertension: thin-section CT predictors of epoprostenol therapy failure.

Author information

1
Department of Radiology, Hôpital Antoine Béclère, 157 rue de la Porte de Trivaux, 92140 Clamart, France. arnaud.resten@abc.ap-hop-paris.fr

Abstract

PURPOSE:

To correlate pretherapeutic thin-section computed tomographic (CT) findings in patients with pulmonary hypertension with the risk of fatality with treatment with epoprostenol.

MATERIALS AND METHODS:

Seventy-three consecutive patients with severe pulmonary hypertension treated with epoprostenol were retrospectively separated into two groups. The first group included 12 patients who had a fatal outcome with epoprostenol therapy. The second group (n = 61) was a reference group of patients with epoprostenol-induced clinical improvement. Pretherapeutic thin-section CT scans of each patient were reviewed.

RESULTS:

Poorly defined nodular opacities (P =.003), septal lines (P =.04), pleural effusion (P =.01), and adenopathy (P =.009) strongly correlated with a risk of clinical worsening with treatment. In six patients in group 1, postmortem examination of the lung revealed either pulmonary veno-occlusive disease or pulmonary capillary hemangiomatosis.

CONCLUSION:

On pretherapeutic thin-section CT scans, poorly defined nodular opacities, septal lines, pleural effusion, and adenopathy should raise suspicion for pulmonary veno-occlusive disease or pulmonary capillary hemangiomatosis and provoke possible further evaluation before epoprostenol therapy.

PMID:
11867801
DOI:
10.1148/radiol.2223010668
[Indexed for MEDLINE]

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