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Am J Public Health. 2002 Mar;92(3):388-94.

Impact of highly active antiretroviral treatment on HIV seroincidence among men who have sex with men: San Francisco.

Author information

1
San Francisco Department of Public Health, 101 Grove Street, Room 308, San Francisco, CA 94102, USA. mitch_katz@dph.sf.ca.us

Abstract

OBJECTIVES:

This study assessed the countervailing effects on HIV incidence of highly active antiretroviral treatment (HAART) among San Francisco men who have sex with men (MSM).

METHODS:

Behavioral risk was determined on the basis of responses to cross-sectional community interviews. HIV incidence was assessed through application of an enzyme-linked immunoassay testing strategy.

RESULTS:

Use of HAART among MSM living with AIDS increased from 4% in 1995 to 54% in 1999. The percentage of MSM who reported both unprotected anal intercourse and multiple sexual partners increased from 24% in 1994 to 45% in 1999. The annual HIV incidence rate increased from 2.1% in 1996 to 4.2% in 1999 among MSM who sought anonymous HIV testing, and the rate was high (5.3%) but stable in a blinded survey of MSM seeking sexually transmitted disease services.

CONCLUSIONS:

Any decrease in per contact risk of HIV transmission due to HAART use appears to have been counterbalanced or overwhelmed by increases in the number of unsafe sexual episodes.

PMID:
11867317
PMCID:
PMC1447086
[Indexed for MEDLINE]
Free PMC Article

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