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Biochem Biophys Res Commun. 2002 Mar 8;291(4):1001-5.

Effect of resveratrol on growth of 4T1 breast cancer cells in vitro and in vivo.

Author information

1
Research Service, Stratton VA Medical Center, Albany, New York 12208, USA. kathleen.bove@med.va.gov

Abstract

In vitro, resveratrol inhibited growth of 4T1 breast cancer cells in a dose- and time-dependent manner. In vivo, however, resveratrol had no effect on time to tumor take, tumor growth, or metastasis when administered intraperitoneally daily (1, 3, or 5 mg/kg) for 23 days starting at the time of tumor inoculation. Resveratrol had no effect on body weight, organ histology, or estrous cycling of the tumor-bearing mice. Resveratrol, therefore, is a potent inhibitor of 4T1 breast cancer cells in vitro; is nontoxic to mice at 1-5 mg/kg; and has no growth-inhibitory effect on 4T1 breast cancer in vivo.

PMID:
11866465
DOI:
10.1006/bbrc.2002.6554
[Indexed for MEDLINE]

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