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Neurology. 2002 Feb 26;58(4):615-20.

Axonal multifocal motor neuropathy without conduction block or other features of demyelination.

Author information

1
Department of Neurology, Palo Alto VA Medical Center and Stanford University, Palo Alto, CA 94304, USA. jskatz@stanford.edu

Abstract

BACKGROUND:

Conduction block is considered an essential finding for the distinction between motor neuropathies and lower motor neuron disorders. Only a small number of reports describe patients with multifocal motor neuropathies who lack overt conduction block, although in these cases other features of demyelination still suggest the presence of a demyelinating disorder. In contrast, a purely axonal multifocal motor neuropathy has not been described.

METHODS:

This report describes nine patients with slowly or nonprogressive multifocal motor neuropathies who had purely axonal electrodiagnostic features.

RESULTS:

GM1 antibodies titers were normal in all nine cases. Six patients were treated with either prednisone or IV immunoglobulin and three showed convincing improvement.

CONCLUSIONS:

These findings suggest an immune-mediated motor neuropathy with axonal electrophysiologic features that appears to be distinct from both multifocal motor neuropathy and established motor neuron disorders.

PMID:
11865141
[Indexed for MEDLINE]
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