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Mol Cell. 2002 Feb;9(2):209-11.

Opening chromatin.

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1
Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032, USA.

Abstract

How the transcriptional apparatus gains access to and subsequently opens compacted chromatin has remained a mystery. Now in this issue of Molecular Cell, Zaret and coworkers show that chromatin opening in vitro is not mediated by the classical chromatin remodeling machines but instead occurs through specific transcription factor-histone interactions.

PMID:
11864594
[Indexed for MEDLINE]
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