Epigenetic reprogramming in the mammalian embryo: struggle of the clones

Mellissa R W Mann; Marisa S Bartolomei

doi:10.1186/gb-2002-3-2-reviews1003

Epigenetic reprogramming in the mammalian embryo: struggle of the clones

Genome Biol. 2002;3(2):REVIEWS1003. doi: 10.1186/gb-2002-3-2-reviews1003. Epub 2002 Jan 29.

Authors

Mellissa R W Mann¹, Marisa S Bartolomei

Affiliation

¹ Howard Hughes Medical Institute and Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA. bartolom@mail.med.upenn.edu

Abstract

During preimplantation development in mammals, distinct epigenetic marks on oocyte and sperm DNA are remodeled to an embryonic pattern. A recent study examining global methylation of repetitive elements in various mammals showed that the reprogramming that occurs during normal preimplantation development is aberrant in cloned embryos.

Publication types

Review

MeSH terms

Animals
Cloning, Organism
DNA Methylation
Embryo, Mammalian / chemistry*
Embryo, Mammalian / metabolism*
Embryo, Nonmammalian*
Embryonic Development / genetics
Female
Genetic Markers / genetics
Genomic Imprinting / genetics*
Interspersed Repetitive Sequences / genetics
Pregnancy

Substances

Genetic Markers