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Genome Biol. 2002;3(2):REVIEWS1003. Epub 2002 Jan 29.

Epigenetic reprogramming in the mammalian embryo: struggle of the clones.

Author information

1
Howard Hughes Medical Institute and Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA. bartolom@mail.med.upenn.edu

Abstract

During preimplantation development in mammals, distinct epigenetic marks on oocyte and sperm DNA are remodeled to an embryonic pattern. A recent study examining global methylation of repetitive elements in various mammals showed that the reprogramming that occurs during normal preimplantation development is aberrant in cloned embryos.

PMID:
11864375
PMCID:
PMC139014
DOI:
10.1186/gb-2002-3-2-reviews1003
[Indexed for MEDLINE]
Free PMC Article

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