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Genome Biol. 2002;3(2):REVIEWS0003. Epub 2002 Jan 29.

Exploring prokaryotic diversity in the genomic era.

Author information

1
ComBinE group, Advanced Computational Modelling Centre, The University of Queensland, Brisbane 4072, Australia. philiph@nature.berkeley.edu

Abstract

Our understanding of prokaryote biology from study of pure cultures and genome sequencing has been limited by a pronounced sampling bias towards four bacterial phyla - Proteobacteria, Firmicutes, Actinobacteria and Bacteroidetes - out of 35 bacterial and 18 archaeal phylum-level lineages. This bias is beginning to be rectified by the use of phylogenetically directed isolation strategies and by directly accessing microbial genomes from environmental samples.

PMID:
11864374
PMCID:
PMC139013
[Indexed for MEDLINE]
Free PMC Article
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