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Med Hypotheses. 2002 Jan;58(1):34-46.

Streptomycin revisited: molecular action in the microbial cell.

Author information

1
Biology Department, Georgia State University, Atlanta, Georgia, USA.

Abstract

The key event for antimicrobial action begins when streptomycin binds to the 30S subunit (S12 protein) of a ribosome. Lysine 42 and lysine 87 are involved. It is proposed that antagonism of acetyl coenzyme A carboxylase by streptomycin results in faulty fatty acids, lipids and derivatives marked exclusively for cell membrane synthesis. Streptomycin-sensitive growing cells are fatally wounded when defective membranes leak K(+) ions, then amino acids, nucleotides, oligonucleotides and proteins as increasing amounts of streptomycin enter the cell.

PMID:
11863397
DOI:
10.1054/mehy.2001.1450
[Indexed for MEDLINE]

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