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J Virol. 2002 Mar;76(6):3045-8.

Porcine endogenous retrovirus transmission characteristics of an inbred herd of miniature swine.

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  • 1Immerge BioTherapeutics, Inc., Charlestown, Massachusetts02129, USA.

Abstract

Here we report the identification of inbred miniature swine that failed to produce human-tropic replication-competent porcine endogenous retroviruses (HTRC PERVs), using in vitro coculture assays. When HTRC PERVs were isolated from transmitting animals, all were recombinant viruses, with the receptor-binding domain of PERV-A combining with PERV-C-related sequences.

PMID:
11861871
PMCID:
PMC135987
[PubMed - indexed for MEDLINE]
Free PMC Article
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