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Curr Opin Neurobiol. 2002 Feb;12(1):57-63.

Sonic hedgehog in the nervous system: functions, modifications and mechanisms.

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Department of Developmental Biology, Howard Hughes Medical Institute, Beckman Center B300, 279 Campus Drive, Stanford University School of Medicine, CA 94305-5329, USA.


Signaling by Sonic hedgehog (Shh) controls important developmental processes, including dorsoventral neural tube patterning, neural stem cell proliferation, and neuronal and glial cell survival. Shh signaling involves lipid modifications to Shh itself, as well as changes in protein subcellular localization. Recent advances have revealed the importance of palmitoylation and acylation of Shh on its potency and migration capacity. Subsequent trafficking and organelle sorting in the Shh signaling pathway have been observed; these observations offer a new dimension to our understanding of downstream signal transduction events.

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