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[Preventive effects of three kinds of inactive vaccines against epidemic hemorrhagic fever (EHF) after 5 years of vaccination].

[Article in Chinese]

Author information

1
Institute of Epidemiology and Microbiology, Chinese Academy of Preventive Medicine, Beijing 102206, China.

Abstract

OBJECTIVE:

To observe the safety and the preventive effects of three kinds of vaccines as Mongolian gerbils kidney vaccine, mouse brains vaccine and hamster kidney vaccine inoculated 5 years ago.

METHODS:

Field study and laboratory tests were carried out by random grouping and IFAT, MCPENT, ELISA, HI tests.

RESULTS:

The antibody-dependent enhancement did not appear in all individuals who received vaccines after four or five years. The seroconversion rates of MCPENT were 8.97%, 11.76% and 18.75% while the seroconversion rates of IFAT were 20.73%, 30.22% and 23.40% respectively for Mongolian gerbils kidney vaccine, mouse brains vaccine and hamster kidney vaccine. The protection rates were 100% for all three kinds of inactive vaccines which showed good epidemiological efficacy.

CONCLUSION:

The vaccines can protect clinical infection of EHF effectively after four or five years of the initial vaccination.

PMID:
11860813
[Indexed for MEDLINE]

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