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Bioorg Med Chem Lett. 2002 Mar 11;12(5):779-82.

Synthesis and activity of a new methoxytetrahydropyran derivative as dual cyclooxygenase-2/5-lipoxygenase inhibitor.

Author information

1
Laboratoires Innothera, avenue P. Vaillant-Couturier, BP 10, 94110, Arcueil, France.

Abstract

Dual COX-2/5-LO inhibitors are described as potential new therapeutic agents for inflammatory diseases. A surprisingly potent effect of a 5-LO pharmacophoric group on the COX-2 inhibition is presented as well as pharmacological in vitro and in vivo results.

PMID:
11859001
DOI:
10.1016/s0960-894x(02)00013-6
[Indexed for MEDLINE]

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