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Am J Obstet Gynecol. 2002 Feb;186(2):288-90.

Erythromycin use during pregnancy in relation to pyloric stenosis.

Author information

1
Slone Epidemiology Unit, Boston University School of Medicine, Brookline, MA 02446, USA. clouik@slone.bu.edu

Abstract

OBJECTIVE:

Newborn infants treated with erythromycin may be at risk for developing pyloric stenosis. Because erythromycin is known to cross the placenta and is a recommended treatment for chlamydia and other infections in pregnancy, we explored whether erythromycin taken during pregnancy might similarly lead to an increase in risk of pyloric stenosis.

STUDY DESIGN:

We used data collected between 1976 and 1998 as part of an ongoing case-control surveillance program. Cases were 1044 infants with a diagnosis of pyloric stenosis. Two control groups were used: 1704 nonmalformed infants and 15,356 infants with a wide range of other malformations. Odds ratios and 95% CIs were calculated by using data from each control group.

RESULTS:

All odds ratio estimates are close to 1.0, all CIs include 1, and all upper 95% confidence bounds are less than 2.0.

CONCLUSION:

We found no evidence of an increased risk of pyloric stenosis among infants born to mothers exposed to erythromycin during pregnancy.

PMID:
11854652
DOI:
10.1067/mob.2002.119718
[Indexed for MEDLINE]

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