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Int J Biochem Cell Biol. 2002 Apr;34(4):321-4.

DNA polymerase beta.

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Laboratory of Structural Biology, NIEHS/NIH, Research Triangle Park, North Carolina, NC 29907, USA.


Mammalian DNA polymerase beta(beta-pol) is a single polypeptide chain enzyme of 39kDa. beta-pol has enzymatic activities appropriate for roles in base excision repair and other DNA metabolism events involving gap-filling DNA synthesis. Many crystal structures of beta-pol complexed with dNTP and DNA substrates have been solved, and mouse fibroblast cell lines deleted in the beta-pol gene have been examined. These approaches have enhanced our understanding of structural and functional aspects of beta-pol's role in protecting genomic DNA.

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