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Trends Endocrinol Metab. 2002 Mar;13(2):55-60.

Nuclear receptor coregulators: multiple modes of modification.

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Department of Medicine, Howard Hughes Medical Institute, University of California, San Diego, 9500 Gilman Drive, 92093-0648, La Jolla, CA 92093-0648, USA.


Many proteins have been characterized as coregulators that can be recruited by DNA-binding nuclear receptors to influence transcriptional regulation. Recent genetic and biochemical studies have shown that cellular levels of coregulators are crucial for nuclear receptor-mediated transcription, and many coregulators have been shown to be targets for diverse intracellular signaling pathways and post-translational modifications. This review focuses on the different modes of regulation of nuclear receptor coregulators and the implications for tissue- and context-specific transcriptional responses to hormone and membrane receptor signaling.

[Indexed for MEDLINE]

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