Abstract
By connecting cytoskeletal elements to each other and to junctional complexes, the plakin family of cytolinkers plays a crucial role in orchestrating cellular development and maintaining tissue integrity. Plakins are built from combinations of interacting domains that bind to microfilaments, microtubules, intermediate filaments, cell-adhesion molecules and members of the armadillo family. Plakins are involved in both inherited and autoimmune diseases that affect the skin, neuronal tissue, and cardiac and skeletal muscle. Here, we describe the members of the plakin family and their interaction partners, and give examples of the cellular defects that result from their dysfunction.
Publication types
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Amino Acid Sequence
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Animals
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Autoantigens / chemistry
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Autoantigens / metabolism*
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Autoimmune Diseases / metabolism
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Carrier Proteins*
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Collagen / chemistry
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Collagen / metabolism*
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Collagen Type XVII
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Cytoskeletal Proteins / chemistry
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Cytoskeletal Proteins / metabolism*
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Desmoplakins
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Dystonin
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Genetic Diseases, Inborn / metabolism
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Humans
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Intermediate Filament Proteins / chemistry
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Intermediate Filament Proteins / metabolism*
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Membrane Proteins / chemistry
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Membrane Proteins / metabolism*
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Microfilament Proteins / chemistry
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Microfilament Proteins / metabolism*
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Molecular Sequence Data
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Nerve Tissue Proteins*
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Non-Fibrillar Collagens*
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Plakins
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Plectin
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Protein Precursors / chemistry
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Protein Precursors / metabolism*
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Sequence Alignment / methods
Substances
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Autoantigens
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Carrier Proteins
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Cytoskeletal Proteins
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DST protein, human
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Desmoplakins
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Dystonin
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Intermediate Filament Proteins
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MACF1 protein, human
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Macf1 protein, mouse
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Membrane Proteins
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Microfilament Proteins
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Nerve Tissue Proteins
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Non-Fibrillar Collagens
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PLEC protein, human
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PPL protein, human
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Plakins
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Plectin
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Protein Precursors
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envoplakin
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epiplakin
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Collagen