Format

Send to

Choose Destination
Biochim Biophys Acta. 2002 Feb 15;1559(2):179-85.

Regulation of jejunal glucose transporter expression by forskolin.

Author information

1
School of Biological Sciences, University of East Anglia, Norwich, UK.

Abstract

We have investigated the effects of forskolin on enterocyte membrane expression of the glucose transporters, SGLT1 and GLUT2, which are thought to be the main entry and efflux pathways for glucose, respectively. Forskolin treatment increased SGLT1 but decreased GLUT2 expression in mid and lower villus enterocytes. No change in transporter expression was noted in upper villus cells. Likewise, cyclic AMP levels were raised in mid and lower but not upper villus cells. The implications of these data for glucose transport are discussed.

PMID:
11853684
DOI:
10.1016/s0005-2736(01)00449-7
[Indexed for MEDLINE]
Free full text

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center