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J Am Chem Soc. 2002 Feb 27;124(8):1658-63.

The formation of polymer vesicles or "peptosomes" by polybutadiene-block-poly(L-glutamate)s in dilute aqueous solution.

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  • 1Max-Planck-Institut für Kolloid- und Grenzflächenforschung, Abteilung Kolloidchemie, Am Mühlenberg 1, D-14476 Golm, Germany.

Abstract

Polybutadiene-block-poly(L-glutamate) copolymers were made by anionic polymerization and subsequent ring-opening polymerization of N-carboxyanhydrides and were characterized by NMR, IR, SEC, and circular dichroism. These polymers, when appropriately designed, form so-called "polymersomes" or "peptosomes", vesicles composed of modified protein units. The size and structure of the vesicles are determined by dynamic light scattering, small-angle neutron scattering, and freeze-fracture electron microscopy. It is also shown that the size of the peptosomes does not depend on the pH; that is, the solvating peptide units can perform a helix-coil transition without serious changes of the vesicle morphology.

PMID:
11853440
[PubMed - indexed for MEDLINE]
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