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Ann Pathol. 2001 Oct;21(5):428-30.

[Malignant mesothelioma with osteoblastic heterologous elements].

[Article in French]

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Service d'anatomie et de cytologie pathologiques, Hôpital Louis Pradel, 28, avenue du Doyen-Lépine, BP Lyon Montchat 69394 Lyon cedex 03, France.


A 59 year-old man with a history of asbestos exposure presented with a right pleural effusion and a diffuse pleural thickening with focal calcifications on chest X-ray. Cytological examination of pleural fluid indicated malignant mesothelioma. A biopsy specimen showed malignant mesothelioma surrounding a fragment of mature bone. The patient was treated with intrapleural interferon, but relapsed 3 years later. A fresh biopsy specimen showed round tumor cells surrounding osteoid substance. Only ten cases of this rare variant of malignant mesothelioma with osteoblastic heterologous elements have been reported in the literature. The most difficult differential diagnosis is primary pleural osteosarcoma.

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