Format

Send to

Choose Destination
See comment in PubMed Commons below
Trends Cardiovasc Med. 2002 Feb;12(2):78-82.

Vasoregulation at the molecular level: a role for the beta1 subunit of the calcium-activated potassium (BK) channel.

Author information

1
Department of Anesthesia, Stanford University Medical Center, CA 94305-5640, USA. ajpanes@leland.stanford.edu

Abstract

Essential hypertension is among the most common and most costly medical conditions in the United States. Multiple defects in the kidneys, the vasculature, and the neuro-endocrine system may contribute to the development of this disorder. Within the past decade investigators have identified several molecular components of the vasculature that control tone and influence blood pressure. For example, the large conductance BK type calcium-activated potassium channel has recently been shown to play an important role in maintaining the dynamic equilibrium between vasoconstriction and vasodilation of vascular smooth muscle. Activation of vascular smooth muscle BK channels leads to hyperpolarization of the cell membrane, which causes deactivation of voltage-dependent calcium channels and vasodilation. In this review, we will summarize recently published data focusing on the role of the BK channel's accessory beta1 subunit as well as other modulators of BK channel activation that influence vascular tone and blood pressure.

PMID:
11852255
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center