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FEBS Lett. 2002 Feb 13;512(1-3):107-10.

Identification of functional VEGF receptors on human platelets.

Author information

1
Department of Biochemistry and Molecular Biology, University of Bergen, Bergen, Norway. frode.selheim@pki.uib.no

Abstract

Platelets secrete platelet-derived growth factor (PDGF) and vascular endothelial growth factor (VEGF) upon stimulation. We have demonstrated that platelets have functionally active PDGF alpha-receptors, a transmembrane tyrosine kinase involved in negative feedback regulation. Here we demonstrate the presence of the related VEGF receptors fms-like tyrosine kinase-1 and kinase-insert domain region on human platelets. VEGF itself did not cause platelet aggregation. However, addition of exogenous VEGF to SFRLLN or thrombin-stimulated platelets potentiated platelet aggregation. Moreover, thrombin-induced phosphoinositide 3-kinase and mitogen-activated protein kinase activity were enhanced in the presence of VEGF.

PMID:
11852061
[Indexed for MEDLINE]
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