Format

Send to

Choose Destination
Oncogene. 2002 Jan 21;21(4):619-26.

Balancing instability: dual roles for telomerase and telomere dysfunction in tumorigenesis.

Author information

1
Predoctoral Training Program in Human Genetics and Molecular Biology, Johns Hopkins University School of Medicine, Baltimore, Maryland, MD 21205, USA.

Abstract

Telomere shortening and telomerase activation both occur in human tumors. Telomere shortening has been proposed to have two conflicting roles in tumorigenesis: tumor suppression and initiation of chromosomal instability. Similarly, while telomerase activation is suggested to be necessary for tumor growth, telomerase may help to stabilize genomic instability. Here we review what is known about these conflicting roles and propose a framework to understand the role of telomerase in cancer progression.

PMID:
11850787
DOI:
10.1038/sj.onc.1205061
[Indexed for MEDLINE]
Free full text

Supplemental Content

Full text links

Icon for Nature Publishing Group
Loading ...
Support Center