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Mech Dev. 2002 Mar;112(1-2):25-36.

Transcription of the Drosophila CKI gene dacapo is regulated by a modular array of cis-regulatory sequences.

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Department of Molecular Genetics, Neurobiotechnology Center, Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210, USA.


Organogenesis requires coordination between developmental programs and cell cycle progression. The Cip/Kip families of cyclin-dependent kinase inhibitor (CKI) are main effectors linking these two programs. In many instances, expression of Cip/Kip CKIs are increased abruptly in cells entering their last mitotic cycle, suggesting that CKI expression is developmentally regulated. Expression of Dacapo (Dap), a Drosophila Cip/Kip CKI, is transiently up-regulated immediately before cells enter G1 arrest. Here we report that dap transcription is controlled by modular arrays of tissues specific cis-regulatory elements. Furthermore, we identified pan-neural Prospero as a regulator of dap transcription in the developing nervous system, providing an example how tissue-specific developmental programs can be linked to cell cycle progression.

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